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the AGE-RAGE signaling, which induces axonal atrophy through p38 MAPK activation (Sango et al., 2025), and the PKC- activation, which impairs nerve blood flow via endothelin-1 overexpression ( Hyperglycemia-induced mitochondrial dysfunction in neuronal and Schwann cells leads to excessive O 2 production at complex I and III of the ETC, which initiates a cascade of injury through four primary mechanisms (Wu L
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Week 12 Improved hydration Healthier skin appearance Enhanced skin vitality Week 36 Gradual improvement in skin radiance More even-looking complexion Noticeable antioxidant benefits Month 24 Progressive skin enhancement Improved overall skin quality Sustained results when combined with professional skincare Individual outcomes may vary depending on lifestyle habits, genetics, sun exposure, and adherence to recommended skincare routines
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